Article: Systemic Monocytic-MDSCs Are Generated from Monocytes and Correlate with Disease Progression in Breast Cancer Patients.

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Bergenfelz C; Larsson AM; von Stedingk K; Gruvberger-Saal S; Aaltonen K; Jansson S; Jernström H; Janols H; Wullt M; Bredberg A; Rydén L; Leandersson K
PLoS ONE, 2015

10.1371/journal.pone.0127028.t001

Table 1 Flow cytometric analysis of leukocyte populations in the peripheral blood of healthy controls (HC), patients with early breast cancer (BC), patients with locoregional recurrence or metastatic breast cancer (LRR/MBC) and patients with sepsis.

		HC	Early BC	LRR/MBC	Sepsis
	Leukocyte population	(median ± SEM) n = 13	(median ± SEM) n = 10	(median ± SEM) n = 23	(median ± SEM) n = 13
Lymphocyte populations	% CD3⁺ cells of PBMCs	34.9 ± 4.1	29.7 ± 2.7	20.4 ± 2.4**	23.1 ± 3.0*
	% CD8⁺ cells of CD3⁺ cells	36.9 ±3.2	26.9 ± 2.7	35.7 ± 2.2	23.9 ± 3.1*
	% CD4⁺ cells of CD3⁺ cells	54.4 ± 3.3	66.5 ± 4.9	60.7 ± 3.4	71.5 ± 4.0**
	CD4:CD8 T cell ratio	1.4 ± 0.4	2.5 ± 0.4*	1.8 ± 0.3	2.9 ± 0.6*
	% CD4⁺CD25⁺CD127^low/- cells of CD4⁺ cells ^a	3.1 ± 0.4	4.0 ± 0.4	3.2 ± 0.5	4.3 ± 0.4
	% CD19⁺ cells of PBMCs	3.6 ± 0.5	3.7 ± 0.5	3.3 ± 1.3 ^b	4.0 ± 0.8
	% CD56⁺CD3^- cells of PBMCs	5.9± 0.6	4.2 ± 0.5	2.5 ± 0.5**	1.9 ± 0.8**
	% CD56⁺CD3⁺ cells of PBMCs	1.6 ± 0.4	1.4 ± 0.7	0.8 ± 0.3*	0.5 ± 0.2**
	% CD56⁺CD3⁺ cells of CD3⁺ cells	7.2 ± 1.0	5.1 ± 2.5	3.9 ± 1.7	2.4 ± 1.0
DC populations	% MDC1 of PBMCs ^c	0.4 ± 0.1	0.3 ± 0.1	0.2 ± 0.0*	0.3 ± 0.0*
	% MDC2 of PBMCs ^d	0.1 ± 0.0	0.0 ± 0.0	0.0 ± 0.0**	0.1 ± 0.0
	% PDC of PBMCs ^e	0.5 ± 0.1	0.6 ± 0.3	0.5 ± 0.2	0.5 ± 0.1

Values are median percentage (±SEM) of population of PBMCs, total CD3⁺ T cell population or total CD4⁺ T cell population. Ratio CD4:CD8 are calculated as percentage CD4⁺ cells / percentage CD8⁺ cells. Statistics by Mann-Whitney Wilcoxon test

* p < 0.05,

** p < 0.01.

^a CD127 was used as an alternative marker for Tregs according to Liu et al 2006 [55].

^b n = 17 for LRR/MBC CD19⁺ cells of PBMCs.

^c MDC1; CD14^-CD19^-CD1c/BDCA-1⁺

^d MDC2; CD14^-CD19^-CD141/BDCA-3^high

^e PDC; CD14^-CD19^-CD303/BDCA-2⁺

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Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source